Jeffrey R Bloomquist, PhD
 |
|
Program Description
The responsibilities of my position (75% research and 25% teaching) are in the areas of toxicology and neuroscience. My research program includes studies of both mammals and insects, and is focused on the interactions of ligand molecules with protein receptors found on cell membranes. These ligand molecules can be drugs, peptides, neurotransmitters, or insecticides. Most of my research is focused on the mechanisms of neurotoxic action of these compounds, along with mechanisms of non-metabolic insecticide resistance. My research approach is multidisciplinary and includes toxicological, neurophysiological, and molecular/biochemical techniques. For over 10 years, my laboratory has been involved in evaluating the Parkinsonian effects of insecticide exposure. For these studies, we have been using the MPTP-treated black mouse model of chemically-induced Parkinsonism. We have found up-regulation of dopamine transporter and alpha-synuclein proteins in the brain of mice treated with low doses of the pyrethroid, permethrin. Other recent studies have evaluated lipophilic cage amines as potential therapeutic agents of Parkinsonism through their ability to block the NMDA-subtype of glutamate receptor in the mammalian brain. New research is assessing the activity of novel, selective insect anticholinesterases for control of malaria-spreading mosquitoes, and blockers of voltage-sensitive chloride channels as nematicides. The courses that form the core of my teaching activities parallel my research interests, and my primary teaching objective is to provide students with well organized, comprehensive, and challenging instruction. I am responsible for two graduate courses in the Department: Insecticide Toxicology (100%), and contribute to Insect Physiology (50%). I also provide 3 hr of guest lectures for a graduate course in the VMRCVM (General Neurochemistry). Involvement in undergraduate instruction includes 6 hr of lecture in Drug Chemistry, given every spring semester. Although I have no extension appointment, I occasionally provide expertise on the toxicology of insecticides to industry and other groups.
Publications and Presentations Summary:
82 publications (book chapters, proceedings chapters, reviews, patents, and refereed journal articles); 70 invited presentations; 92 volunteered presentations
Recent Publications
J. Kou and J. R. Bloomquist. Neurotoxicity in Murine Striatal Dopaminergic Pathways Following Long-Term Application of Low Doses of Permethrin and MPTP. Toxicol. Lett. 171, 154-161 (2007).
W. J. Geldenhuys, S. F. Malan, J. R. Bloomquist, and C. J. Van Der Schyf. Structure-Activity Relationships of Pentacycloundecylamines at the N-Methyl-D-Aspartic Acid Receptor. Bioorg. Med. Chem. 15(3), 1525-1532 (2007).
R. J. Cordero, J. R. Bloomquist, and T. P. Kuhar. Susceptibility of Two Diamondback Moth Parasitoids, Diadegma insulare (Cresson) (Hymenoptera; Ichneumonidae) and Oomyzus sokolowskii (Kurdjumov) (Hymenoptera; Eulophidae), to Selected Commercial Insecticides. Biol. Control 42, 48–54 (2007).
J. Kou, D. C. Klorig, and J. R. Bloomquist. Potentiating Effect of The ATP-Sensitive Potassium Channel Blocker Glibenclamide on Complex I Inhibitor Neurotoxicity In Vitro and In Vivo. NeuroToxicology 27, 826-834 (2006).
R. J. Cordero, T. P. Kuhar, J. Speese III, R. R. Youngman, E. E. Lewis, J. R. Bloomquist, L. T. Kok, and A. D. Bratsch. Field Efficacy of Insecticides for Control of Lepidopteran Pests on Collards in Virginia. Plant Health Prog. On-line journal: http://www.plantmanagementnetwork.org/sub/php/research/2006/collard/ (2006).
J. Kou, J. G. Gillette, and J. R. Bloomquist. Neurotoxicity in Striatal Dopaminergic Pathways Following Co-application of Permethrin, Chlorpyrifos, and MPTP. Pestic. Biochem. Physiol. 85, 68-75 (2006).
R. R. Youngman, J. R. Bloomquist, J. B. Hall, S. L. Paulson, and W. D. Whittier. Agricultural Animal Pest Control: A Guide for Livestock Managers in Virginia. Virginia Agricultural Experiment Station #456-215 (2006).
W. J. Geldenhuys, S. F. Malan, J. R. Bloomquist, A. P. Marchand, and C. J. Van der Schyf. Pharmacology and Chemistry of Polycyclic Cage-derived Compounds. Medicinal Res. Rev . 25, 21-48 (2005).
W. J. Geldenhuys, S. F. Malan, T. Murugesan, C. J. Van der Schyf, and J. R. Bloomquist. Synthesis and Biological Evaluation of Pentacyclo[5.4.0.02,6.03,10.05,9]-undecane Derivatives as Potential Therapeutic Agents in Parkinson’s Disease. Bioorg. Med. Chem. 12, 1799-1806 (2004).
J. S. Gillette and J. R. Bloomquist. Differential Up-Regulation of Striatal Dopamine Transporter and alpha-Synuclein by the Pyrethroid Insecticide Permethrin. Toxicol. Appl. Pharmacol. 192, 287-293 (2003).
Recent Invited Presentations (presenter underlined)
J. Bloomquist. 2007. Cyclodiene-induced alterations in mammalian dopaminergic pathways as a possible cause of environmentally-induced Parkinsonism. Invited speaker, Agrochemicals Division International Award Symposium for Gerald Brooks, National Meeting of the American Chemical Society, Chicago, Illinois.
J. Bloomquist. 2007. Research into Control of the Malaria Mosquito, Anopheles gambiae, Using Novel Anticholinesterases. Dept. of Entomology, Michigan State University, East Lansing, Michigan.
J. Bloomquist. 2007. Bivalent Anticholinesterases: New Chemistry for an Old Target. Dept. of Entomology, Cornell University, Ithaca and Geneva, New York.
J. Bloomquist, P. Carlier, E. Wong, and S. Paulson. 2006. Novel anticholinesterases for control of the malaria mosquito, Anopheles gambiae. Vector-Borne Disease Research: The Road Ahead, October 13-15, 2006, Blacksburg, Virginia.
J. R. Bloomquist. 2005. Molecular Design of Selective Anticholinesterases for Mosquito Control. Kick off meeting of the FNIH Grand Challenges in Global Health program, Seattle, WA. Bill and Melinda Gates attended this meeting, and all travel costs of the speakers and project collaborators was paid for by the Bill and Melinda Gates Foundation.
J. R. Bloomquist. 2005. Impact of Insecticide exposure in the MPTP-treated C57 mouse model of Parkinson's disease. University of Massachusetts, Department of Veterinary and Animal Science, Biomedicine and Biotechnology Program, Amherst, MA.
Recent Volunteered Presentations (presenter underlined)
P. R. Carlier, J. R. Bloomquist, D. M. Wong, L. D. Williams, N. Deora, T. Anderson, S. Paulson, A. Wysinski, E. Wong, R. Choudury, M. Totrov, and P. Lam. 2007. Development of a mosquito-selective AChE inhibitor to control the malaria vector, Anopheles gambiae. Ninth International Meeting on Cholinesterase Biology, Suzhou, China.
J. M. Mutunga, T. D. Anderson, and J. R. Bloomquist. 2007. Exploring the insect acetylcholinesterase (AChE) active site gorge: Toxicokinetic and AChE sequence analysis as prospects to molecular design of selective insecticides. Bioinformatics for Africa Conference and Workshop, Nairobi, Kenya.
T. D. Anderson, D. C. Klorig, #D. Wong, P. R. Carlier, S. L. Paulson and J. R. Bloomquist. 2007. Biochemical and molecular characterization of bivalent anticholinesterases to the malarial mosquito. Poster, National Meeting of the American Chemical Society, Chicago, Illinois.
J. R. Bloomquist and D. R. Boina. 2006. Analogs of a Bacterial Stilbene as New Insecticides/Nematicides. Poster; 11TH IUPAC International Congress of Pesticide Chemistry, Kobe, Japan.
J. R. Bloomquist, D. C. Klorig, D. Wong, and P. R. Carlier. 2006. Bivalent anticholinesterases as structural probes in the development of selective mosquitocides. Poster; 11TH IUPAC International Congress of Pesticide Chemistry, Kobe, Japan.
J. R. Bloomquist and D. R. Boina. 2006. Blockers of Anion Transporters as Nematicidal Alternatives to Methyl Bromide. Symposium speaker; National Meeting of the American Chemical Society, Division of Agrochemicals, San Francisco, California.
D. R. Boina and J. R. Bloomquist. 2006. Lethal and sublethal effects of anion transport blockers against larvae of European corn borer, Ostrinia nubilalis (Hubner). Poster, National Meeting of the Entomological Society of America, Indianapolis, Indiana.
T. D. Anderson, D. C. Klorig, D. R. Boina, D. Wong, P. R. Carlier, S. L. Paulson and J. R. Bloomquist. 2006. Bivalent anticholinesterases as structural probes in the development of selective mosquitocides. Poster, National Meeting of the Entomological Society of America, Indianapolis, Indiana.
J. Kou and J. R. Bloomquist. 2005. Potentiating Effect of the K+atp Channel Blocker Glibenclamide on the Neurotoxicity of Complex I Inhibitors. Poster, 22nd International Neurotoxicology Conference; Environment and Neurodevelopmental Disorders, Research Triangle Park, North Carolina.
W. J. Geldenhuys, D. C. Klorig, S. F. Malan, J. R. Bloomquist, and C. J. Van der Schyf. 2005. Pharmacological Evaluation of Adamantane Amines that Bind to the PCP and Not the MK-801 Binding Site in the N-Methyl-D-Aspartate (NMDA) Receptor. Poster, National Meeting of the Society for Neuroscience, Washington, D.C.
J. R. Bloomquist, E. Chow Clement, Y. Zhang, and P. R. Carlier. 2005. Synthesis and Pharmacology of New Dimeric Amides and ZAPA Analogs at the Murine GABAA Receptor-Chloride Channel Complex. Poster, National Meeting of the Society for Neuroscience, Washington, D.C.
Blurb last modified at 2007-07-30 15:33:55.0.
